Get emergency medical help if you have signs of an allergic reaction to Vicodin: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. In rare cases, acetaminophen may cause a severe skin reaction that can be fatal. My husband has been taking vicodin for pain for 4 years since he had a hip replacement. He has changed tremendouly, VERY negative, explosive, reads the news paper, as usual, for cover to cover and TALKS about all the bad things. Painkillers like Vicodin aren't prescribed as antidepressants. to continuously abuse painkillers to “treat” their depression, it would cause the depression to worsen in the long run. Why does taking Vicodin affect your sleep? Why Might Prescription Painkillers Lead to Depression? It's not entirely clear how the drugs may be involved in depression , although it is widely known that they have a strong impact on your brain. The drugs work by binding to receptors in your brain to decrease the perception of pain. Does Vicodin Help Depression. – Do you have an addiction to Hydrocodone and need help? Our treatment facilities and trained counselors offer the greatest care. – Do you have an addiction to Hydrocodone and need help? close What To Expect. Seeking addiction treatment can feel overwhelming. We know the struggle, which is why we're uniquely qualified to help. Your call is confidential, and there's no pressure to commit to treatment until you're ready. They can give them advice and help talk about their problems and help them to know why they have depression, how to deal with it, what to do if considering suicide and all types of subjects like. Vicodin does nothing NOTHING AT ALL. for depression but make it worse.matter of fact if you are not depressed it's a sure fire way to feel depressed after usage esculates. that was your original question anyway. Sep 10, 2015. My brother killed himself more than a dozen years ago. You know people do take Vicodin for the buzz sometimes, maybe he just took too much..